Catalog Number: 4349
Chemical Name: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
Biological Activity
Antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM). Atypical antipsychotic. Displays anticholinergic properties.
Technical Data
  • M.Wt:
    312.43
  • Formula:
    C17H20N4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    132539-06-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.
    Moore et al.
    J.Pharmacol.Exp.Ther., 1992;262:545
  2. Radioreceptor binding profile of the atypical antipsychotic olanzapine.
    Bymaster et al.
    Neuropsychopharmacology, 1996;14:87
  3. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Olanzapine include:

1 Citations: Showing 1 - 1

  1. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    Nat Methods 2015;40:766
Tocris Small Molecules
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Olanzapine - d8

5542  
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