Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7
-dehydrocholesterol reductase (IC50
= 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo
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Cholesterol in signal transduction.
Incardona and Eaton
Curr.Opin.Cell Biol., 2000;12:193
Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944.
Kraml et al.
Molecular cloning and expression of the human Δ7-sterol reductase.
Moebius et al.
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Cooper et al.