AY 9944 dihydrochloride

   
Product Datasheet
Catalog Number:1639
Chemical Name:trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
Product Details
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Biological Activity
Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.
Technical Data
  • M.Wt:
    464.3
  • Formula:
    C22H28Cl2N2.2HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    366-93-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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