Catalog Number: 1639
Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
Biological Activity
Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cholesterol in signal transduction.
    Incardona and Eaton
    Curr.Opin.Cell Biol., 2000;12:193
  2. Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944.
    Kraml et al.
    Biochem.Biophys.Res.Commun., 1964;15:455
  3. Molecular cloning and expression of the human Δ7-sterol reductase.
    Moebius et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:1899
  4. Teratogen-mediated inhibition of target tissue response to Shh signaling.
    Cooper et al.
    Science, 1998;280:1603

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