AY 9944 dihydrochloride
Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
Biological ActivityAY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.
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Complete Your Research
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Cooper et al.
Cholesterol in signal transduction.
Incardona and Eaton
Curr.Opin.Cell Biol., 2000;12:193
Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944.
Kraml et al.
Molecular cloning and expression of the human Δ7-sterol reductase.
Moebius et al.
Citation for AY 9944 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AY 9944 dihydrochloride include:
1 Citation: Showing 1 - 1
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
Authors: Kant Et al.
Cell Stem Cell 2019;24:363
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