AY 9944 dihydrochloride

Catalog # Availability Size / Price Qty
1639/10

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

AY 9944 dihydrochloride | CAS No. 366-93-8 | Hedgehog Signaling Inhibitors
1 Image
Description: Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase

Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.

Technical Data

M.Wt:
464.3
Formula:
C22H28Cl2N2.2HCl
Solubility:
Soluble to 50 mM in water and to 5 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
366-93-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Teratogen-mediated inhibition of target tissue response to Shh signaling.
    Cooper et al.
    Science, 1998;280:1603
  2. Cholesterol in signal transduction.
    Incardona and Eaton
    Curr.Opin.Cell Biol., 2000;12:193
  3. Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944.
    Kraml et al.
    Biochem.Biophys.Res.Commun., 1964;15:455
  4. Molecular cloning and expression of the human Δ7-sterol reductase.
    Moebius et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:1899

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for AY 9944 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AY 9944 dihydrochloride include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AY 9944 dihydrochloride

There are currently no reviews for this product. Be the first to review AY 9944 dihydrochloride and earn rewards!

Have you used AY 9944 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.