AZ 1729

Catalog # Availability Size / Price Qty
AZ 1729 | CAS No. 2016864-46-1 | Free Fatty Acid Receptor Agonists
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Description: FFA2 allosteric agonist; displays bias for the Gi signaling pathway

Chemical Name: 4-Fluoro-N-[3-[2-[(aminoiminomethyl)amino]-4-methyl-5-thiazolyl]phenyl]benzamide

Purity: ≥98%

Product Details

Biological Activity

AZ 1729 is a FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 5 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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