Potent DYRK1B inhibitor (IC50
values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi
phase cell cycle arrest in Panc-1 cells in vitro
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A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3� to phosphorylate cyclin D1 at Thr(286), not Thr(288).
Ashford et al.