Chemical Name: N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
Biological ActivityAZ 191 is a potent DYRK1B inhibitor (IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ 191 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3� to phosphorylate cyclin D1 at Thr(286), not Thr(288).
Ashford et al.
Citations for AZ 191
The citations listed below are publications that use Tocris products. Selected citations for AZ 191 include:
2 Citations: Showing 1 - 2
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.
Authors: Martin Et al.
Dev Cell 2020;55:629-647.e7
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Authors: Blake Et al.
Sci Signal 2019;12
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