Chemical Name: N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
Biological ActivityPotent DYRK1B inhibitor (IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3� to phosphorylate cyclin D1 at Thr(286), not Thr(288).
Ashford et al.
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