Potent and selective PFKFB3 inhibitor (IC50
= 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50
values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50
= 0.343 μM). Exhibits no significant inhibition of other kinases.
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All Tocris products are intended for laboratory research use only.
Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3.
Boyd et al.