AZ PFKFB3 26

Key Product Details

Product Description

AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor (IC₅₀ = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC₅₀ values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC₅₀ = 0.343 μM). Exhibits no significant inhibition of other kinases.

Product Specifications for AZ PFKFB3 26

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZ PFKFB3 26

The following data is based on the product molecular weight 402.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.42 mL	24.85 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Boyd Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 2015 PMID: 25849762

Product Documents for AZ PFKFB3 26