AZ PFKFB3 67

Tocris Bioscience | Catalog # 5742

Potent and selective PFKFB3 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective PFKFB3 inhibitor
View all PFKFB3 Inhibitors »

Product Description

AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).

Product Specifications for AZ PFKFB3 67

Molecular Weight

455.51

Formula

C26H25N5O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide

CAS Number

1704741-11-6

PubChem ID

91668554

InChI Key

NDIKFKQBWGMLCA-DEOSSOPVSA-N

SMILES

N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.55 100
Ethanol 45.55 100

Preparing Stock Solutions for AZ PFKFB3 67

The following data is based on the product molecular weight 455.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.20 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.20 mL 4.39 mL
10 mM 0.22 mL 1.10 mL 2.20 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for AZ PFKFB3 67

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZ PFKFB3 67

For research use only

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