AZD 1208

Catalog # Availability Size / Price Qty
AZD 1208 | CAS No. 1204144-28-4 | Pim Kinase Inhibitors
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Description: Potent pan Pim kinase inhibitor

Chemical Name: (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

AZD 1208 is a potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. AZD 1208 downmodulates the expression of Mayaro virus (MAYV) structural protein E1 and non-structural protein 1 (nsP1), and it reduces MAYV replication in a dose-dependent manner in HeLa or HDFs cells. Chemosensitizer.

Technical Data

Soluble to 20 mM in DMSO with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for AZD 1208

The citations listed below are publications that use Tocris products. Selected citations for AZD 1208 include:

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