AZD 1480

Catalog # Availability Size / Price Qty
5617/10
Cat.No. 5617 - AZD 1480 | C14H14ClFN8 | CAS No. 935666-88-9
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Description: Potent and selective JAK2 inhibitor; antiangiogenic

Chemical Name: 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.

Technical Data

M.Wt:
348.77
Formula:
C14H14ClFN8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
935666-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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