Chemical Name: 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
Biological ActivityPotent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule immuno-oncology therapeutic agents.
Toogood et al.
Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists.
Kindon et al.
ACS Med.Chem.Lett., 2017;8:981
Cancer charity sees success re-prioritizing industry's shelved compounds.
Mullard et al.
Nat.Rev.Drug Discov., 2014;13:319
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