AZD 2098

Catalog # Availability Size / Price Qty
6541/50
6541/10
Chemokine Receptor Antagonists Small Molecule
1 Image
Description: Potent and selective CCR4 antagonist

Chemical Name: 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.

Technical Data

M.Wt:
334.18
Formula:
C11H9Cl2N3O3S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
566203-88-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small molecule immuno-oncology therapeutic agents.
    Toogood et al.
    Bioorg.Med.Chem.Lett., 2017;S0960:31218
  2. Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists.
    Kindon et al.
    ACS Med.Chem.Lett., 2017;8:981
  3. Cancer charity sees success re-prioritizing industry's shelved compounds.
    Mullard et al.
    Nat.Rev.Drug Discov., 2014;13:319

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