AZD 5582 dihydrochloride

Tocris Bioscience | Catalog # 5141

Dimeric Smac mimetic; potent IAP inhibitor
Tocris Bioscience

Key Product Details

Description

Dimeric Smac mimetic; potent IAP inhibitor
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Product Description

AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd

Product Specifications for AZD 5582 dihydrochloride

Molecular Weight

1088.21

Formula

C58H78N8O8.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide

CAS Number

1883545-51-4

PubChem ID

90489014

InChI Key

DAILKFFMJFAUCE-GXSVUDMFSA-N

SMILES

CN[C@@H](C)C(N[C@@H]([C@H]1CCCCC1)C(N2[C@H]([C@](N[C@H]3C(C=CC=C5)=C5C[C@H]3OCC#CC#CCO[C@@H]4CC8=C(C=CC=C8)[C@@H]4N[C@@]([C@H](CCC7)N7C([C@H]([C@H]6CCCCC6)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 108.82 100
DMSO 108.82 100

Preparing Stock Solutions for AZD 5582 dihydrochloride

The following data is based on the product molecular weight 1088.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.92 mL 4.59 mL 9.19 mL
5 mM 0.18 mL 0.92 mL 1.84 mL
10 mM 0.09 mL 0.46 mL 0.92 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for AZD 5582 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZD 5582 dihydrochloride

For research use only

Citations for AZD 5582 dihydrochloride

Customer Reviews for AZD 5582 dihydrochloride (1)

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  • It worked good
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: colorectal cancer cells
    Verified Customer | Posted 07/12/2020
    10 µM
    AZD 5582 dihydrochloride 5141

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