AZD 5582 dihydrochloride

Catalog # Availability Size / Price Qty
5141/10
AZD 5582 dihydrochloride | CAS No. 1883545-51-4 | Other ER Stress/UPR Inhibitors
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Description: Dimeric Smac mimetic; potent IAP inhibitor

Chemical Name: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

Technical Data

M.Wt:
1088.21
Formula:
C58H78N8O8.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1883545-51-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd

Product Datasheets

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Citation for AZD 5582 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AZD 5582 dihydrochloride include:

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