AZD 7762 hydrochloride

Key Product Details

Product Description

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC₅₀ vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications for AZD 7762 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 7762 hydrochloride

The following data is based on the product molecular weight 398.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.54 mL	25.07 mL
5 mM	0.50 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Morgan Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G₂ checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res. 2010 PMID: 20501833
• Ma Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells. Nat Commun. 2018 PMID: 29610531
• Zabludoff AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008 PMID: 18790776

Product Documents for AZD 7762 hydrochloride