B I09

Key Product Details

Product Description

B I09 is an IRE-1 RNase inhibitor (IC₅₀ = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Product Specifications for B I09

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for B I09

The following data is based on the product molecular weight 303.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.59 mL	32.97 mL	65.94 mL
2.5 mM	1.32 mL	6.59 mL	13.19 mL
5 mM	0.66 mL	3.30 mL	6.59 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Tang Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 2014 PMID: 24812669

Product Documents for B I09