Chemical Name: 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-benzopyrano[3,4-c]pyridin-5-one
Biological ActivityB I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Tang et al.
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