Chemical Name: 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-benzopyrano[3,4-c]pyridin-5-one
Biological ActivityB I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Tang et al.
Citation for B I09
The citations listed below are publications that use Tocris products. Selected citations for B I09 include:
1 Citation: Showing 1 - 1
Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers.
Authors: Andrew V Et al.
Cancer Res 2021;81:5325-5335
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