Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Biological ActivityBaicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules.
Hsu et al.
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
Nakahata et al.
Selective inhibition of platelet lipoxygenase by baicalein.
Sekiya and Okuda
Identification of Baicalein as a ferroptosis inhibitor by natural product library screening.
Xie et al.
Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway.
Hsieh et al.
Citations for Baicalein
The citations listed below are publications that use Tocris products. Selected citations for Baicalein include:
6 Citations: Showing 1 - 6
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Authors: Oguh-Olayinka Et al.
Pathol Oncol Res 2019;
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.
Authors: Mishra Et al.
Nat Microbiol 2017;2:17072
12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.
Authors: Maskrey Et al.
PLoS One 2014;11:33
Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
Authors: Potapova Et al.
PLoS One 2013;8:e73929
Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
Authors: Starowicz Et al.
PLoS One 2013;8:e60040
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
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