Baicalein

  ( 4 citations )    
Product Datasheet
Catalog Number:1761
Chemical Name:5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Product Details
Citations (4)
Reviews
Biological Activity
Inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation.
Technical Data
  • M.Wt:
    270.24
  • Formula:
    C15H10O5
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    491-67-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Baicalein include:

4 Citations: Showing 1 - 4
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  1. 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.
    Authors: Maskrey Et al.
    PLoS One  2014;11:33
  2. Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
    Authors: Potapova Et al.
    PLoS One  2013;8:e73929
  3. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
    Authors: Starowicz Et al.
    PLoS One  2013;8:e60040
  4. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
    Authors: Gibson Et al.
    Neuron  2008;57:746

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