Catalog Number: 1761
Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Biological Activity
Inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules.
    Hsu et al.
    Eur.J.Pharmacol., 2001;425:165
  2. Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
    Nakahata et al.
    Eur.J.Pharmacol., 2003;461:1
  3. Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway.
    Hsieh et al.
    Clin.Mol.Allergy, 2007;26:5
  4. Selective inhibition of platelet lipoxygenase by baicalein.
    Sekiya and Okuda
    Biochem.Biophys.Res.Commun., 1982;105:1090

The citations listed below are publications that use Tocris products. Selected citations for Baicalein include:

3 Citations: Showing 1 - 3
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  1. 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.
    Authors: Maskrey Et al.
    PLoS One 2014;11:33
  2. Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
    Authors: Potapova Et al.
    PLoS One 2013;8:e73929
  3. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
    Authors: Gibson Et al.
    Neuron 2008;57:746

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