Inhibitor of 5- and platelet 12-lipoxygenases (IC50
values are 9.5 and 0.12 μ
M respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1
cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κ
Soluble to 50 mM in DMSO
Desiccate at -20°C
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Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules.
Hsu et al.
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
Nakahata et al.
Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway.
Hsieh et al.
Selective inhibition of platelet lipoxygenase by baicalein.
Sekiya and Okuda
The citations listed below are publications that use Tocris products. Selected citations for Baicalein include:
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