Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Biological ActivityBAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers.
Kenwood et al.
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood et al.
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Axelrod et al.
EMBO Mol.Med., 2020;:doi: 10.15252
Citations for BAM 15
The citations listed below are publications that use Tocris products. Selected citations for BAM 15 include:
2 Citations: Showing 1 - 2
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Authors: Styr Et al.
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