Catalog Number: 5737
Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Biological Activity
Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.
Technical Data
  • M.Wt:
    340.29
  • Formula:
    C16H10F2N6O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    210302-17-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers.
    Kenwood et al.
    Bioorg.Med.Chem.Lett., 2015;25:4858
  2. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
    Kenwood et al.
    Mol.Metab., 2013;3:114

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