BAM 15

Key Product Details

Product Description

BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC₅₀ = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

Product Specifications for BAM 15

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BAM 15

The following data is based on the product molecular weight 340.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.39 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Kenwood Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 2013 PMID: 24634817
• Axelrod BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. 2020 PMID: 32519812
• Kenwood Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 2015 PMID: 26119501

Product Documents for BAM 15