Bax inhibitor peptide V5
Biological Activity
Bax inhibitor peptide V5 is a cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. Designed based on the Bax-binding domain of human Ku70. Inhibits Bax-mediated apoptosis in vitro. Shown to inhibit anti-cancer drug-induced apoptosis in vitro.Control Peptide also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.
Sawatzky et al.
Am.J.Pathol., 2006;168:33 -
Bax-inhibiting peptide derived from mouse and rat Ku70.
Yoshida et al.
Biochem.Biophys.Res.Commun., 2004;321:961
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Citations for Bax inhibitor peptide V5
The citations listed below are publications that use Tocris products. Selected citations for Bax inhibitor peptide V5 include:
2 Citations: Showing 1 - 2
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Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisp. via enhancing apoptosis pathways in vitro and in vivo.
Authors: Lin Et al.
Toxicol Sci 2014;139:108
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Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells.
Authors: Lee Et al.
J Cell Sci 2010;123:1634
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