Catalog Number: 1785
Biological Activity
Cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. Designed based on the Bax-binding domain of human Ku70. Inhibits Bax-mediated apoptosis in vitro. Shown to inhibit anti-cancer drug-induced apoptosis in vitro.

Control Peptide also available.

Technical Data
  • M.Wt:
    586.79
  • Formula:
    C27H50N6O6S
  • Sequence:
    VPMLK
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    579492-81-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Other Product-Specific Information:
Background References
  1. Bax-inhibiting peptide derived from mouse and rat Ku70.
    Yoshida et al.
    Biochem.Biophys.Res.Commun., 2004;321:961
  2. The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.
    Sawatzky et al.
    Am.J.Pathol., 2006;168:33
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bax inhibitor peptide V5 include:

1 Citations: Showing 1 - 1

  1. Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells.
    Authors: Lee Et al.
    J Cell Sci 2010;123:1634

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