10 results for "Bcl-2 Family Inhibitors" in Products
Bcl-2 Family Inhibitors
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. They comprise a large protein family and all members contain at least one of four BH (Bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-XL and Mcl-1 are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
The proapoptotic group of Bcl-2 proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (including Bid, NOXA, PUMA and Bad) and the multidomain ...
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
| Alternate Names: | Venetoclax,GDC-0199 |
| Chemical Name: | 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide |
| Purity: | ≥98% |
Glucocorticoid receptor agonist
| Chemical Name: | 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione |
| Purity: | ≥98% |
High affinity and selective activator of Bax
| Chemical Name: | 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol |
| Purity: | ≥98% |
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
| Chemical Name: | 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide |
| Purity: | ≥98% |
Allosteric inhibitor of Bax channel activation
| Alternate Names: | BAI1 |
| Chemical Name: | 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride |
| Purity: | ≥98% |
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
| Alternate Names: | Filanesib |
| Chemical Name: | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate |
| Purity: | ≥98% |
Inhibitor of Bcl-2 family members; antiapoptotic
| Alternate Names: | GX15-070 |
| Chemical Name: | 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate |
| Purity: | ≥98% |
Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
| Chemical Name: | 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid |
| Purity: | ≥98% |
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
| Chemical Name: | 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide |
| Purity: | ≥98% |
Molecular glue; induces degradation of BCL6
| Chemical Name: | rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one |
| Purity: | ≥98% |
