BAY 41-8543

Key Product Details

Product Description

BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Product Specifications for BAY 41-8543

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BAY 41-8543

The following data is based on the product molecular weight 420.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.78 mL	118.92 mL	237.85 mL
0.5 mM	4.76 mL	23.78 mL	47.57 mL
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Hoffmann Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat.Commun. 2015 PMID: 26011238
• Stasch Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br.J.Pharmacol. 2002 PMID: 11815368

Product Documents for BAY 41-8543