Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μ
M. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro
. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.
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Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.
Stasch et al.
Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue.
Hoffmann et al.