Catalog Number: 5708
Chemical Name: 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
Biological Activity
Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.
Technical Data
  • M.Wt:
    420.44
  • Formula:
    C21H21FN8O
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    256498-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.
    Stasch et al.
    Br.J.Pharmacol., 2002;135:333
  2. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue.
    Hoffmann et al.
    Nat.Commun., 2015;6:7235
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