BAY 58-2667 hydrochloride

Name: BAY 58-2667 hydrochloride
Brand: Tocris Bioscience
SKU: 6052
Price: 314 USD
Availability: InStock

Tocris Bioscience | Catalog # 6052

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Citations (2)

Product Documents

Potent soluble guanylyl cyclase (sGC) activator

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent soluble guanylyl cyclase (sGC) activator

Alternative Names

Cinaciguat hydrochloride

View all Guanylyl Cyclase Activators »

Product Description

BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC₅₀ = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Product Specifications for BAY 58-2667 hydrochloride

Molecular Weight

602.16

Formula

C₃₆H₃₉NO₅.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride

CAS Number

646995-35-9

PubChem ID

10031513

InChI Key

LLHMBJOVHATVSP-UHFFFAOYSA-N

SMILES

OC(CCCCN(CC1=CC=C(C(O)=O)C=C1)CCC2=C(C=CC=C2)OCC3=CC=C(C=C3)CCC4=CC=CC=C4)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	60.22	100

Preparing Stock Solutions for BAY 58-2667 hydrochloride

The following data is based on the product molecular weight 602.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.30 mL	16.61 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Calculators

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Mass

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Stasch Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 2006 PMID: 16955146
Roy Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 2008 PMID: 18204474
Stasch NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 2002 PMID: 12086987

Product Documents for BAY 58-2667 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for BAY 58-2667 hydrochloride

For research use only

Citations for BAY 58-2667 hydrochloride

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