BAY 58-2667 hydrochloride
Chemical Name: 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
Biological ActivityBAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle.
Stasch et al.
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
Stasch et al.
Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.
Roy et al.
Citation for BAY 58-2667 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BAY 58-2667 hydrochloride include:
1 Citation: Showing 1 - 1
Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.
Authors: Cheng Et al.
Arterioscler Thromb Vasc Biol 2019;:ATVBAHA119312725
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for BAY 58-2667 hydrochloride
There are currently no reviews for this product. Be the first to review BAY 58-2667 hydrochloride and earn rewards!
Have you used BAY 58-2667 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image