Chemical Name: 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Biological ActivityBAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases.
von Nussbaum et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for BAY 678
There are currently no reviews for this product. Be the first to review BAY 678 and earn rewards!
Have you used BAY 678?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image