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BAY 8002

Catalog #: 6817 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6817/50
6817/10
BAY 8002 | CAS No. 724440-27-1 | Monocarboxylate Transporter Inhibitors
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Description: Potent dual MCT1/2 inhibitor; orally bioavailable

Chemical Name: 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid

Purity: ≥98%

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Biological Activity

BAY 8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC50 values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC50 = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.

Technical Data

M.Wt:
415.85
Formula:
C20H14ClNO5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
724440-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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