BAY 826 New
Chemical Name: [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Biological ActivityPotent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs). Selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. Displays in vivo efficacy in some murine glioma models.
Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models.
Schneider et al.
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