BAY 826

Catalog # Availability Size / Price Qty
BAY 826 | CAS No. 1448316-08-2 | Additional RTK Inhibitors
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Description: Potent Tie2 inhibitor

Chemical Name: [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur

Product Details

Biological Activity

Potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs). Selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. Displays in vivo efficacy in some murine glioma models.

Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.

Product Datasheets

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