BC 11-38
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Purity: ≥98%
Biological Activity
Selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.
Ceyhan et al.
Chem.Biol., 2012;19:155
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Citation for BC 11-38
The citations listed below are publications that use Tocris products. Selected citations for BC 11-38 include:
1 Citation: Showing 1 - 1
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p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation.
Authors: Lu and Sewer
J Biol Chem 2015;35:1223
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