Selective phosphodiesterase (PDE) 11 inhibitor (IC50
= 0.28 μ
M for PDE11; IC50
values are >100 μ
M for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
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Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.
Ceyhan et al.
The citations listed below are publications that use Tocris products. Selected citations for BC 11-38 include:
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