Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Biological ActivitySelective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.
Ceyhan et al.
Citation for BC 11-38
The citations listed below are publications that use Tocris products. Selected citations for BC 11-38 include:
1 Citation: Showing 1 - 1
p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation.
Authors: Lu and Sewer
J Biol Chem 2015;35:1223
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