Catalog Number: 4496
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Biological Activity
Selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
Technical Data
  • M.Wt:
    304.43
  • Formula:
    C15H16N2OS2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    686770-80-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.
    Ceyhan et al.
    Chem.Biol., 2012;19:155
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BC 11-38 include:

1 Citations: Showing 1 - 1

  1. p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation.
    Authors: Lu and Sewer
    J Biol Chem 2015;35:1223

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