BC 11 hydrobromide

Catalog # Availability Size / Price Qty
4372/10
4372/50
Urokinase Inhibitors Small Molecule
1 Image
Description: Selective urokinase (uPA) inhibitor

Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide

Product Details
Citations (3)
Reviews

Biological Activity

Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Technical Data

M.Wt:
290.97
Formula:
C8H11BN2O2S.HBr
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
Storage:
Store at -20°C
CAS No:
443776-49-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Elucidating novel urokinase-type plasminogen activator inhibitors.
    Smith et al.
    Int.Soc.Thromb.Haemost. (Abstract), 2011;9:819
  2. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells
    Longo et al.
    Molecules, 2015;20:9879

Product Datasheets

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Citations for BC 11 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:

3 Citations: Showing 1 - 3

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