BC 11 hydrobromide (CAS 443776-49-6): R&D Systems
Catalog Number: 4372
Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Biological Activity
Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.
Technical Data
  • M.Wt:
    290.97
  • Formula:
    C8H11BN2O2S.HBr
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
  • Storage:
    Store at -20°C
  • CAS No:
    443776-49-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Elucidating novel urokinase-type plasminogen activator inhibitors.
    Smith et al.
    Int.Soc.Thromb.Haemost. (Abstract), 2011;9:819
  2. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells
    Longo et al.
    Molecules, 2015;20:9879
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:

1 Citations: Showing 1 - 1

  1. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching.
    Authors: Semina Et al.
    Eur.J.Cell Biol. 2016;95:295

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