BC 11 hydrobromide

Tocris Bioscience | Catalog # 4372

Selective urokinase (uPA) inhibitor
Tocris Bioscience

Key Product Details

Description

Selective urokinase (uPA) inhibitor
View all Urokinase Inhibitors »

Product Description

BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Product Specifications for BC 11 hydrobromide

Molecular Weight

290.97

Formula

C8H11BN2O2S.HBr

Storage

Store at -20°C

Chemical Name

Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide

CAS Number

443776-49-6

PubChem ID

78243712

InChI Key

PAFZAMOVHIRQOD-UHFFFAOYSA-N

SMILES

NC(SCC1=CC=C(B(O)O)C=C1)=N.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.82 20 with gentle warming
DMSO 29.1 100

Preparing Stock Solutions for BC 11 hydrobromide

The following data is based on the product molecular weight 290.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.18 mL 34.37 mL
5 mM 0.69 mL 3.44 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for BC 11 hydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BC 11 hydrobromide

For research use only

Related Research Areas

Serine Proteases and Regulators

Citations for BC 11 hydrobromide

Customer Reviews for BC 11 hydrobromide (1)

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  • Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: rat astroglioma C6 cells
    Verified Customer | Posted 03/24/2020
    20 µM
    BC 11 hydrobromide 4372

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