BC 11 hydrobromide
Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Biological ActivityBC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Elucidating novel urokinase-type plasminogen activator inhibitors.
Smith et al.
Int.Soc.Thromb.Haemost. (Abstract), 2011;9:819
Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells
Longo et al.
Citations for BC 11 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:
3 Citations: Showing 1 - 3
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
Cleavage of the urok. receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.
Authors: Magnussen Et al.
BMC Cancer 2017;17:350
Urokinase and urok. receptor participate in regulation of neuronal migration, axon growth and branching.
Authors: Semina Et al.
Eur.J.Cell Biol. 2016;95:295
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