BD 1063 dihydrochloride

Catalog # Availability Size / Price Qty
0883/10
0883/50
BD 1063 dihydrochloride | CAS No. 206996-13-6 | Sigma1 Receptor Ligands
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Description: Selective σ1 ligand, putative antagonist

Chemical Name: 1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride

Purity: ≥99%

Product Details
Citations (17)
Reviews (2)

Biological Activity

σ1 receptor antagonist, approximately 50-fold selective over σ2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α1, α2, β adrenoceptor, 5-HT1 and 5-HT2 receptors. Prevents hyperlocomotion following cocaine administration in mice.

Technical Data

M.Wt:
346.13
Formula:
C13H18Cl2N2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
206996-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BD 1063 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BD 1063 dihydrochloride include:

17 Citations: Showing 1 - 10

  1. The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease.
    Authors: Cortés-Montero Et al.
    Antioxid Redox Signal  2019;
  2. The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.
    Authors: Sánchez-Blázquez Et al.
    Mol Neurobiol  2018;55:4940
  3. Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2018;21:938
  4. Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
    Authors: Rodríguez-Muñoz Et al.
    Mol Brain  2018;11:51
  5. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol  2015;6:35458
  6. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
    Authors: Nguyen Et al.
    PLoS One  2014;9:e89985
  7. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
    Authors: Smith Et al.
    Mol Pharmacol  2014;86:390
  8. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Oncotarget  2014;350:290
  9. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
    Authors: Pabba Et al.
    J Neurosci  2014;34:11325
  10. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Nat Chem Biol  2014;17:1943

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BD1063 binds to sigma-1 receptor
By Timur Mavlyutov on 02/26/2018
Application: Species: Mouse

We used BD1063 compound as a sigma-1 receptor protector against photolabeling by radioactive iodoazidofenpropimorph in mouse spinal cord homogenate and saw good protective effect with concentration of 10uM.


Use of BD 1063 in mouse brain slices
By Jordan Yorgason on 01/05/2018
Application: Species: Mouse

We used BD 1063 as a selective sigma antagonist to test if methamphetamine effects on dopamine release involved sigma receptor activation. BD 1063 (100nM) was applied before methamphetamine treatment. Drug was easy to use, and Tocris' recommendation on concentration for selectivity was useful for the study.

PMID: 29185481 Reference

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