BD 1063 dihydrochloride

  ( 12 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0883
Chemical Name:1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
σ1 receptor antagonist, approximately 50-fold selective over σ2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α1, α2, β adrenoceptor, 5-HT1 and 5-HT2 receptors. Prevents hyperlocomotion following cocaine administration in mice.
Technical Data
  • M.Wt:
    346.13
  • Formula:
    C13H18Cl2N2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    206996-13-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BD 1063 dihydrochloride include:

12 Citations: Showing 1 - 10
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  1. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol  2015;6:35458
  2. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
    Authors: Nguyen Et al.
    PLoS One  2014;9:e89985
  3. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
    Authors: Smith Et al.
    Mol Pharmacol  2014;86:390
  4. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Oncotarget  2014;350:290
  5. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
    Authors: Pabba Et al.
    J Neurosci  2014;34:11325
  6. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Nat Chem Biol  2014;17:1943
  7. Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action.
    Authors: Zhang Et al.
    PLoS One  2013;7:e51910
  8. Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation.
    Authors: Iñiguez Et al.
    Front Pharmacol  2013;4:23
  9. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
    Authors: Kourrich Et al.
    Cell  2013;152:236
  10. A 96-well filtration method for radioligand binding analysis of σ receptor ligands.
    Authors: Fishback Et al.
    J Pharm Biomed Anal  2012;71:157
  11. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther  2011;339:662
  12. beta-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms.
    Authors: Kurata Et al.
    J Pharmacol Exp Ther  2004;311:237
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Average Rating: 5 (Based on 2 reviews)

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  Mouse Timur Mavlyutov 02/26/2018
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  Excellent
  Mouse Jordan Yorgason 01/05/2018
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Pub Med ID 29185481

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