Catalog Number: 5184
Alternate Names: Blood depressing substance 1
Biological Activity
Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge: 4-39,6-32,22-40)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4.
    Diochot et al.
    J.Biol.Chem., 1998;273:6744
  2. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.
    Liu et al.
    J.Neurophysiol., 2012;107:3155
  3. Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.
    Pannaccione et al.
    Mol.Pharmacol., 2007;72:665
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