Potent and reversible Kv
3.4 potassium channel blocker (IC50
= 47 nM); also attenuates inactivation of sodium currents by acting on Nav
1.7 and Nav
1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.
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All Tocris products are intended for laboratory research use only.
Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4.
Diochot et al.
Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.
Liu et al.
Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.
Pannaccione et al.