Chemical Name: N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride
Biological ActivityCalcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacology of bepridil.
Gill et al.
Bepridil block of cardiac calcium and sodium channels.
Yatani et al.
Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes.
Wantanabe and Kimura
Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.
Sato et al.
Citation for Bepridil hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:
1 Citation: Showing 1 - 1
Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities.
Authors: Ciapa and Philippe
PLoS One 2013;8:e66113
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Product used on Cav1.2 channels to understand it blocking mechanism on the specific channel.