Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Biological ActivityBexarotene is a potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
Boehm et al.
Brown adipogenic reprogramming induced by a small molecule.
Nie et al.
Cell Rep., 2017;18:624
A selective retinoid X receptor agonist bexar. (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours.
Yen et al.
Citations for Bexarotene
The citations listed below are publications that use Tocris products. Selected citations for Bexarotene include:
2 Citations: Showing 1 - 2
Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction.
Authors: McCullough Et al.
Transl Psychiatry 2018;8:164
Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro.
Exp Cell Res 2017;361(1):101
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Bexarotene has limited solubility in water, thus it was dissolved in pure DMSO prior to injection and injected i.p. at 50 mg/kg in a volume of 0.03 ml using an insulin syringe.