Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Biological ActivityPotent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
Boehm et al.
A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours.
Yen et al.
Brown adipogenic reprogramming induced by a small molecule.
Nie et al.
Cell Rep., 2017;18:624
Citation for Bexarotene
The citations listed below are publications that use Tocris products. Selected citations for Bexarotene include:
1 Citation: Showing 1 - 1
Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro.
Exp Cell Res 2017;361(1):101
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