Potent and selective RXR agonist (EC50
values are 24, 25 and 33 nM for RXRβ
, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro
, and inhibits metastasis and angiogenesis in mouse models.
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All Tocris products are intended for laboratory research use only.
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
Boehm et al.
A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours.
Yen et al.