Bexarotene

Tocris Bioscience | Catalog # 5819

Potent and selective RXR agonist
Tocris Bioscience

Key Product Details

Description

Potent and selective RXR agonist

Alternative Names

LGD 1069
View all Retinoid X Receptor Agonists »

Product Description

Bexarotene is a potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Product Specifications for Bexarotene

Molecular Weight

348.48

Formula

C24H28O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

CAS Number

153559-49-0

PubChem ID

82146

InChI Key

NAVMQTYZDKMPEU-UHFFFAOYSA-N

SMILES

CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.85 100
Ethanol 6.97 20 with gentle warming

Preparing Stock Solutions for Bexarotene

The following data is based on the product molecular weight 348.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.70 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for Bexarotene

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bexarotene

For research use only

Customer Reviews for Bexarotene (1)

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  • CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Rosa26 fs-TRAP (B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J)
    Verified Customer | Posted 02/08/2020
    Bexarotene has limited solubility in water, thus it was dissolved in pure DMSO prior to injection and injected i.p. at 50 mg/kg in a volume of 0.03 ml using an insulin syringe.
    Bexarotene 5819

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