Catalog Number: 5819
Alternate Names: LGD 1069
Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Biological Activity
Potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.
Technical Data
  • M.Wt:
    348.48
  • Formula:
    C24H28O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    153559-49-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
    Boehm et al.
    J.Med.Chem., 1994;37:2930
  2. A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours.
    Yen et al.
    Br.J.Cancer, 2006;94:654
  3. Brown adipogenic reprogramming induced by a small molecule.
    Nie et al.
    Cell Rep., 2017;18:624

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