Bexarotene

Catalog # Availability Size / Price Qty
5819/10
5819/50
Bexarotene | CAS No. 153559-49-0 | Retinoid X Receptor Agonists
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Description: Potent and selective RXR agonist
Alternative Names: LGD 1069

Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Bexarotene is a potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Technical Data

M.Wt:
348.48
Formula:
C24H28O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
153559-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Bexarotene

The citations listed below are publications that use Tocris products. Selected citations for Bexarotene include:

2 Citations: Showing 1 - 2

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CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction
By Anonymous on 02/08/2020
Application: Species: Mouse

Bexarotene has limited solubility in water, thus it was dissolved in pure DMSO prior to injection and injected i.p. at 50 mg/kg in a volume of 0.03 ml using an insulin syringe.

PMID: 30135420

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