Catalog Number: 3743
Chemical Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride
Biological Activity
Histamine H3 receptor inverse agonist (EC50 = 1.5 nM) and antagonist (Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.
Technical Data
  • M.Wt:
    332.31
  • Formula:
    C17H26ClNO.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    903576-44-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.
    Ligneau et al.
    Biochem.Pharmacol., 2007;73:1215
  2. BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.
    Ligneau et al.
    J.Pharm.Exp.Ther., 2007;320:365

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