BF 2649 hydrochloride

Key Product Details

Product Description

BF 2649 hydrochloride is a potent and selective histamine H₃ receptor inverse agonist (EC₅₀ = 1.5 nM, K_i = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.

Product Specifications for BF 2649 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BF 2649 hydrochloride

The following data is based on the product molecular weight 332.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.05 mL	30.09 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.50 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Ligneau BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H₃ receptor: Preclinical pharmacology. J.Pharm.Exp.Ther. 2007 PMID: 17005916
• Ligneau Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochem.Pharmacol. 2007 PMID: 17343831

Product Documents for BF 2649 hydrochloride