BGP 15

Catalog # Availability Size / Price Qty
6703/5
6703/25
BGP 15 | CAS No. 66611-37-8 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: PARP inhibitor; cytoprotectant

Chemical Name: N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

PARP inhibitor (IC50 = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. Also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

Technical Data

M.Wt:
351.27
Formula:
C14H22N4O2.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
66611-37-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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