BI 01383298

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BI 01383298 | CAS No. 2227549-00-8 | Other Ion Pump/Transporter Inhibitors
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Description: Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor

Chemical Name: 1-[(3,5-Dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide

Purity: ≥98%

Product Details

Biological Activity

BI 01383298 is a potent and selective inhibitor of human SLC13A5 (Na+/citrate cotransporter; IC50 = 56 nM in HEK cells overexpressing hSLC13A5 and 24 nM in HepG2 cells with endogenous SLC13A5 expression). Displays >1000-fold selectivity over other family members.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI01383298 probe summary on the SGC website.

Background References

  1. Flipping a citrate switch on liver cancer cells.
    J.Biol.Chem., 2017;292:13902

Product Datasheets

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