BI 01383298

Catalog # Availability Size / Price Qty
6518/25
6518/5
Other Ion Pump/Transporter Inhibitors Small Molecule
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Description: Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor

Chemical Name: 1-[(3,5-Dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective inhibitor of human SLC13A5 (Na+/citrate cotransporter; IC50 = 56 nM in HEK cells overexpressing hSLC13A5 and 24 nM in HepG2 cells with endogenous SLC13A5 expression). Displays >1000-fold selectivity over other family members.

Technical Data

M.Wt:
445.34
Formula:
C19H19Cl2FN2O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2227549-00-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI01383298 probe summary on the SGC website.

Background References

  1. Flipping a citrate switch on liver cancer cells.
    Peters
    J.Biol.Chem., 2017;292:13902

Product Datasheets

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