BI 4394

Key Product Details

Product Description

BI 4394 is a highly potent and selective MMP-13 inhibitor (IC₅₀ = 1 nM). BI 4394 inhibits the degradation of isolated bovine nasal cartilage explants (IC₅₀ = 31 nM). It shows high selectivity (>1000 fold) for MMP-13 over other MMPs. In vivo, BI 4394 decreases the mean arthritic score vs control in a murine model of rheumatoid arthritis, when administered at a dose of 100 mg/kg over a 14-day period. BI 4394 is orally bioavailable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 4394 page on the SGC website.

Product Specifications for BI 4394

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BI 4394

The following data is based on the product molecular weight 446.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.40 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Taylor Indole inhibitors of MMP-13 for arthritic disorders. ACS Omega 2021 PMID: 34337203
• Taylor Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J.Med.Chem. 2011 PMID: 22017539

Product Documents for BI 4394