Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Biological ActivityBI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
HNF4α antagonists discovered by a high-throughput screen for modulators of the human Ins promoter.
Kiselyuk et al.
Citations for BI 6015
The citations listed below are publications that use Tocris products. Selected citations for BI 6015 include:
2 Citations: Showing 1 - 2
Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma.
Authors: Hu Et al.
Front Pharmacol 2018;9:1150
Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection
Authors: Levy Et al.
Nature Chemical Biology 2016;12:1037
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