Hepatocyte nuclear factor 4α
) antagonist. Represses expression of known HNF4α
target genes. Decreases HNF4α
DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.
Kiselyuk et al.