BI 9321

Key Product Details

Product Description

BI 9321 is a nuclear receptor-binding SET domain (NSD) 3 antagonist (IC₅₀ = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (K_d = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9321 probe summary on the SGC website.

Product Specifications for BI 9321

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BI 9321

The following data is based on the product molecular weight 469.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.64 mL	21.29 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Böttcher Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 2019 PMID: 31285596

Product Documents for BI 9321