BI 9321

Catalog # Availability Size / Price Qty
6665/5
BI 9321 | Lysine Methyltransferase Inhibitors
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Description: Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain

Chemical Name: (4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

Technical Data

M.Wt:
469.81
Formula:
C22H21FN4.3HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9321 probe summary on the SGC website.

Background References

  1. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
    Böttcher et al.
    Nat.Chem.Biol., 2019;15:822

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