Catalog Number: 2981
Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Biological Activity
Selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
Technical Data
  • M.Wt:
    331.36
  • Formula:
    C21H17NO3
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    321674-73-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity.
    Rankin et al.
    Anticancer Drugs, 2008;19:329
  2. A highly selective telomerase inhibitor limiting human cell proliferation.
    Damm et al.
    EMBO J., 2001;20:6958
  3. Telomerase and its potential for therapeutic intervention.
    Phatak and Burger
    Br.J.Pharmacol., 2007;152:1003
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BIBR 1532 include:

1 Citations: Showing 1 - 1

  1. Telomerase efficiently elongates highly transcribing telomeres in human cancer cells.
    Authors: Farnung Et al.
    PLoS One 2012;7:e35714

Have you used BIBR 1532?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information