Catalog Number: 2981
Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Biological Activity
Selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity.
    Rankin et al.
    Anticancer Drugs, 2008;19:329
  2. A highly selective telomerase inhibitor limiting human cell proliferation.
    Damm et al.
    EMBO J., 2001;20:6958
  3. Telomerase and its potential for therapeutic intervention.
    Phatak and Burger
    Br.J.Pharmacol., 2007;152:1003

The citations listed below are publications that use Tocris products. Selected citations for BIBR 1532 include:

1 Citations: Showing 1 - 1

  1. Telomerase efficiently elongates highly transcribing telomeres in human cancer cells.
    Authors: Farnung Et al.
    PLoS One 2012;7:e35714

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