Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Biological ActivityBIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A highly selective telomerase inhibitor limiting human cell proliferation.
Damm et al.
EMBO J., 2001;20:6958
Telomerase and its potential for therapeutic intervention.
Phatak and Burger
Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity.
Rankin et al.
Anticancer Drugs, 2008;19:329
Citations for BIBR 1532
The citations listed below are publications that use Tocris products. Selected citations for BIBR 1532 include:
2 Citations: Showing 1 - 2
Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation.
Authors: Beyer Et al.
Circ Res 2016;118:856
Telomerase efficiently elongates highly transcribing telomeres in human cancer cells.
Authors: Farnung Et al.
PLoS One 2012;7:e35714
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Reviews for BIBR 1532
Average Rating: 3 (Based on 1 Review)
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Used BIBR 1532 as telomerase inhibitor at 2.5 uM with reproducible but moderate effects (expected).