Bicifadine hydrochloride

Key Product Details

Product Description

Bicifadine hydrochloride is a potent antagonist of the noradrenalin transporter (IC₅₀ = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC₅₀ values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.

Product Specifications for Bicifadine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bicifadine hydrochloride

The following data is based on the product molecular weight 209.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.77 mL	23.84 mL	47.68 mL
5 mM	0.95 mL	4.77 mL	9.54 mL
10 mM	0.48 mL	2.38 mL	4.77 mL
50 mM	0.10 mL	0.48 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Basile Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 2007 PMID: 17325229
• Epstein 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 1981 PMID: 7241504

Product Documents for Bicifadine hydrochloride