BigLEN (mouse)
Tocris Bioscience | Catalog # 6304
GPR171 agonist
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Product Description
BigLEN (mouse) is a GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.
Product Specifications for BigLEN (mouse)
Molecular Weight
1756.03
Formula
C78H130N24O22
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
501036-69-7
PubChem ID
131648250
InChI Key
UEWHHQZTIIRRRA-REWHPCPNSA-N
SMILES
[H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Mack Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 2019 PMID: 30726666
- Wardman ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS One 2011 PMID: 22164236
Product Documents for BigLEN (mouse)
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for BigLEN (mouse)
For research use only
Related Research Areas
Citations for BigLEN (mouse)
Customer Reviews for BigLEN (mouse) (1)
5 out of 5
1 Customer Rating
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Species: MouseAssay Type: Ex VivoCell Line/Tissue: Lymphoid CellsVerified Customer | Posted 07/07/2022I used this to screen for the activation of cell activity. I found the ideal concentrations to be around 1 - 25 uM to be ideal for my needs. It performed as expected and was easy to reconstitute. It stored at 2 mg/mL at -20C for more than 3months.
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