Biological ActivityBigLEN (mouse) is a GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.
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ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake.
Wardman et al.
Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation.
Mack et al.
ACS Chem.Neurosci., 2019;10:1884
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