Chemical Name: 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
Biological ActivityBIIB 021 is a selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
Lundgren et al.
Mol.Cancer Ther., 2009;8:921
BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.
Yin et al.
Citation for BIIB 021
The citations listed below are publications that use Tocris products. Selected citations for BIIB 021 include:
1 Citation: Showing 1 - 1
Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.
Authors: Catherine B Et al.
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