BIIB 021

Discontinued Product

4608 has been discontinued.
View all HSP90 Inhibitors products.
BIIB 021 | CAS No. 848695-25-0 | HSP90 Inhibitors
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Description: Selective Hsp90 inhibitor
Alternative Names: CNF 2024

Chemical Name: 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

BIIB 021 is a selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for BIIB 021

The citations listed below are publications that use Tocris products. Selected citations for BIIB 021 include:

1 Citation: Showing 1 - 1

  1. Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.
    Authors: Catherine B Et al.
    Immunology  2021;162:84-91


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