BIIB 021

Tocris Bioscience | Catalog # 4608

Selective Hsp90 inhibitor
Tocris Bioscience
Discontinued Product
4608 has been discontinued. View all HSP90 Inhibitors products.

Key Product Details

Description

Selective Hsp90 inhibitor

Alternative Names

CNF 2024
View all HSP90 Inhibitors »

Product Description

BIIB 021 is a selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

Product Specifications for BIIB 021

Molecular Weight

318.76

Formula

C14H15ClN6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine

CAS Number

848695-25-0

PubChem ID

16736529

InChI Key

QULDDKSCVCJTPV-UHFFFAOYSA-N

SMILES

ClC1=C2C(N(CC3=NC=C(C)C(OC)=C3C)C=N2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.88 100

Preparing Stock Solutions for BIIB 021

The following data is based on the product molecular weight 318.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.69 mL 31.37 mL
5 mM 0.63 mL 3.14 mL 6.27 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for BIIB 021

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIIB 021

For research use only

Customer Reviews for BIIB 021 (1)

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  • BIIB 021 induces PARP cleavage in U2OS cells
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 03/25/2019
    Human osteosarcoma, U2OS, cells were treated with BIIB 021 (1 microM) for 24 h to follow PARP cleavage using Western blot. BIIB 021 activated PARP cleavage in U2OS cells
    BIIB 021 4608

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