receptor full agonist (KD
= 77 nM and EC50
= 18 nM for wild type 5-HT4
receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
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Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
Pellissier et al.
Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives.
Schaus et al.
The citations listed below are publications that use Tocris products. Selected citations for BIMU 8 include:
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