Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
Biological ActivityPotent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
Pellissier et al.
Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives.
Schaus et al.
Citations for BIMU 8
The citations listed below are publications that use Tocris products. Selected citations for BIMU 8 include:
2 Citations: Showing 1 - 2
5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions
Authors: Wang Et al.
Scientific Reports 2016;6:37336
Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.
Authors: House Et al.
PLoS One 2015;29:323
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