Catalog Number: 4374
Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
Biological Activity
Potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
Technical Data
  • M.Wt:
    378.9
  • Formula:
    C19H26N4O2.HCl
  • Solubility:
    Soluble to 75 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    134296-40-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
    Pellissier et al.
    Mol.Pharmacol., 2009;75:982
  2. Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives.
    Schaus et al.
    J.Med.Chem., 1998;41:1943
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BIMU 8 include:

2 Citations: Showing 1 - 2
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  1. 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions
    Authors: Wang Et al.
    Scientific Reports 2016;6:37336
  2. Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.
    Authors: House Et al.
    PLoS One 2015;29:323

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