Selective, high affinity α4β1
(Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1
= 70 pM; IC50
= 0.004 μ
M). Selective for α4β1
over a range of other integrins (IC50
M for α1β1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
Muro et al.
Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand.
Chen et al.
Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses.
Lin et al.
The citations listed below are publications that use Tocris products. Selected citations for BIO 1211 include:
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