Biological ActivityBIO 1211 is a selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand.
Chen et al.
Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses.
Lin et al.
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
Muro et al.
Citations for BIO 1211
The citations listed below are publications that use Tocris products. Selected citations for BIO 1211 include:
3 Citations: Showing 1 - 3
Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with the anti-GD2 ganglioside antibody 14G2a.
Authors: Hanna Et al.
Int J Oncol 2017;50:1899-1914
Early reprogramming regulators identified by prospective isolation and mass cytometry.
Authors: Lujan Et al.
The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action.
Authors: Fujita Et al.
PLoS One 2014;9:e93738
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
VersaClone cDNA Plasmids
Reviews for BIO 1211
There are currently no reviews for this product. Be the first to review BIO 1211 and earn rewards!
Have you used BIO 1211?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image