Catalog Number: 3910
Biological Activity
Selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
Technical Data
  • M.Wt:
    708.8
  • Formula:
    C36H48N6O9
  • Sequence:
    MPUPA-LDVP
  • Solubility:
    Soluble to 2 mg/ml in 0.2M PBS
  • Storage:
    Store at -20°C
  • CAS No:
    187735-94-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
    Muro et al.
    J.Med.Chem., 2009;52:7974
  2. Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand.
    Chen et al.
    J.Biol.Chem., 1999;274:13167
  3. Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses.
    Lin et al.
    J.Med.Chem., 1999;42:920
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BIO 1211 include:

2 Citations: Showing 1 - 2
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  1. Early reprogramming regulators identified by prospective isolation and mass cytometry.
    Authors: Lujan Et al.
    Nature 2015;521:352
  2. The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action.
    Authors: Fujita Et al.
    PLoS One 2014;9:e93738

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