Biological ActivityBIO 1211 is a selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand.
Chen et al.
Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses.
Lin et al.
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
Muro et al.
Citations for BIO 1211
The citations listed below are publications that use Tocris products. Selected citations for BIO 1211 include:
2 Citations: Showing 1 - 2
Early reprogramming regulators identified by prospective isolation and mass cytometry.
Authors: Lujan Et al.
The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action.
Authors: Fujita Et al.
PLoS One 2014;9:e93738
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VersaClone cDNA Plasmids
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