Catalog #: 4336-100-02
6 Citations Datasheet / COA / SDS

Discontinued Product

4336-100-02 has been discontinued.
View all PAR/pADPr products.
Product Details
Citations (6)

Biotin(Terminal)-PAR Summary

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Preparation and Storage

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: PAR/pADPr

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Long Name
Poly [ADP-ribose] Polymer
Alternate Names
pADPr; PAR; Poly(ADP-ribose)

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Citations for Biotin(Terminal)-PAR

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1
    Authors: WL Lin, JK Chen, X Wen, W He, GA Zarceno, Y Chen, S Chen, TT Paull, HW Liu
    Cell Reports, 2022-07-19;40(3):111089.
    Species: Human
    Sample Types: Proteins
    Applications: Bioassay
  2. PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair
    Authors: B Peng, R Shi, J Bian, Y Li, P Wang, H Wang, J Liao, WG Zhu, X Xu
    Nucleic Acids Research, 2021-07-21;49(13):7554-7570.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Immunoprecipitation
  3. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation
    Authors: SM Hoang, N Kaminski, R Bhargava, J Barroso-Go, ML Lynskey, L García-Exp, JL Roncaioli, AR Wondisford, CT Wallace, SC Watkins, DI James, ID Waddell, D Ogilvie, KM Smith, F da Veiga L, D Mellachare, AI Nesvizhski, J Li, D Ray-Gallet, RW Sobol, G Almouzni, RJ O'Sullivan
    Nat Struct Mol Biol, 2020-10-12;0(0):.
    Species: Human
    Sample Types: Reference Standard
  4. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites
    Authors: Y Chen, H Zhang, Z Xu, H Tang, A Geng, B Cai, T Su, J Shi, C Jiang, X Tian, A Seluanov, J Huang, X Wan, Y Jiang, V Gorbunova, Z Mao
    Nucleic Acids Res., 2019-09-19;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  5. The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response
    Authors: Q Zhang, ASA Mady, Y Ma, C Ryan, TS Lawrence, Z Nikolovska, Y Sun, MA Morgan
    Nucleic Acids Res., 2019-05-07;0(0):.
    Applications: Surface Plasmon Resonance
  6. The CHD6 chromatin remodeler is an oxidative DNA damage response factor
    Authors: S Moore, ND Berger, MS Luijsterbu, CG Piett, FKT Stanley, CU Schräder, S Fang, JA Chan, DC Schriemer, ZD Nagel, H van Attiku, AA Goodarzi
    Nat Commun, 2019-01-16;10(1):241.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation


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