Biperiden hydrochloride

Key Product Details

Product Description

Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M₁ subtype (K_i values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M₁, M₄, M₃, M₂ and M₅ receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Product Specifications for Biperiden hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Biperiden hydrochloride

The following data is based on the product molecular weight 347.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.74 mL	143.71 mL	287.42 mL
0.5 mM	5.75 mL	28.74 mL	57.48 mL
1 mM	2.87 mL	14.37 mL	28.74 mL
5 mM	0.57 mL	2.87 mL	5.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sudo Muscarinic receptor occupancy by bipe. in living human brain. Life Sci. 1999 PMID: 10069534
• Brocks Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci.
• Bolden Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 1992 PMID: 1346637

Product Documents for Biperiden hydrochloride