Biperiden hydrochloride

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2853/10
2853/50
Biperiden hydrochloride | CAS No. 1235-82-1 | mAChR M1 Antagonists
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Description: Muscarinic receptor antagonist; some selectivity for M1
Alternative Names: Akineton

Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol hydrochloride

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Biological Activity

Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Technical Data

Formula:
C21H29NO.HCl
Solubility:
Soluble to 5 mM in water and to 10 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1235-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells.
    Bolden et al.
    J.Pharmacol.Exp.Ther., 1992;260:576
  2. Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective.
    Brocks
    J.Pharm.Pharmaceut.Sci., 1999;2:39
  3. Muscarinic receptor occupancy by bipe. in living human brain.
    Sudo et al.
    Life Sci., 1999;64:PL99

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