Catalog Number: 2853
Alternate Names: Akineton
Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol hydrochloride
Biological Activity
Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
Technical Data
  • M.Wt:
    347.92
  • Formula:
    C21H29NO.HCl
  • Solubility:
    Soluble to 5 mM in water and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1235-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells.
    Bolden et al.
    J.Pharmacol.Exp.Ther., 1992;260:576
  2. Muscarinic receptor occupancy by biperiden in living human brain.
    Sudo et al.
    Life Sci., 1999;64:PL99
  3. Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective.
    Brocks
    J.Pharm.Pharmaceut.Sci., 1999;2:39

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