BIRT 377
Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
Purity: ≥98%
Biological Activity
Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.
Wu et al.
J.Med.Chem., 2004;47:5356 -
Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion.
Kelly et al.
J.Immunol., 1999;163:5173 -
Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction.
Last-Barney et al.
J.Am.Chem.Soc., 2001;123:5643
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Citation for BIRT 377
The citations listed below are publications that use Tocris products. Selected citations for BIRT 377 include:
1 Citation: Showing 1 - 1
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LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes.
Authors: Noor Et al.
Neuroimmunol Neuroinflammation 2019;6:11
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