Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
Biological ActivityPotent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.
Wu et al.
Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion.
Kelly et al.
Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction.
Last-Barney et al.
Citation for BIRT 377
The citations listed below are publications that use Tocris products. Selected citations for BIRT 377 include:
1 Citation: Showing 1 - 1
LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes.
Authors: Noor Et al.
Neuroimmunol Neuroinflammation 2019;6:11
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