BIRT 377

Catalog # Availability Size / Price Qty
4776/10
4776/50
BIRT 377 | CAS No. 213211-10-0 | Integrin Receptor Inhibitors
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Description: Potent negative allosteric modulator of LFA-1

Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.

Technical Data

M.Wt:
442.13
Formula:
C18H15BrCl2N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
213211-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for BIRT 377

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