Catalog Number: 5908
Chemical Name: 4,4'-Bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonic acid dipotassium salt
Biological Activity
Fluorescent probe for nonpolar cavities in proteins. Used to detect Aβ fibre (Kd = ~80 nM); exhibits distinct fluorescent profiles for fibres and oligomers. Fluoresces in hydrophobic environments, negligible fluorescence in water solutions. Excitation\emission λ ~ 355\520 nm at pH 7.4.
Technical Data
  • M.Wt:
    672.85
  • Formula:
    C32H22K2N2O6S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in water
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    65664-81-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dimer formation from 1-amino-8-naphthalenesulfonate catalyzed by bovine serum albumin. A new fluorescent molecule with exceptional binding properties.
    Rosen et al.
    Biochemistry, 1969;8:3915
  2. A comparison of three fluorophores for the detection of amyloid fibers and prefibrillar oligomeric assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid).
    Younan et al.
    Biochemistry, 2015;54:4297
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