Bisindolylmaleimide II

Catalog # Availability Size / Price Qty
4128/10
4128/50
Cat.No. 4128 - Bisindolylmaleimide II | C27H26N4O2 | CAS No. 137592-45-1
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Description: Potent PKC inhibitor and nicotinic receptor antagonist

Chemical Name: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 μM). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2μM for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

Technical Data

M.Wt:
438.52
Formula:
C27H26N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
137592-45-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for Bisindolylmaleimide II

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