Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50
= 0.01 μ
M). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50
values are 0.75 and 2μ
M for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC50
~ 0.03 μ
M for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Toullec et al.
Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.
Mahata et al.
The citations listed below are publications that use Tocris products. Selected citations for Bisindolylmaleimide II include:
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