Bisindolylmaleimide II

Catalog # Availability Size / Price Qty
4128/10
4128/50
Protein Kinase C Inhibitors Small Molecule
1 Image
Description: Potent PKC inhibitor; also potent nAChR antagonist

Chemical Name: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

Purity: ≥97%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 μM). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2μM for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

Technical Data

M.Wt:
438.52
Formula:
C27H26N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
137592-45-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Bisindolylmaleimide II

The citations listed below are publications that use Tocris products. Selected citations for Bisindolylmaleimide II include:

2 Citations: Showing 1 - 2

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BII upregulates GABA-dependent affects of GABA-A receptor
By Anonymous on 07/21/2019
Species: Rat

Bisindolylmaleimide II (BII) was used to block PKC in hippocampal granule cells. Such a block enhances activity of GABA receptors and, as a sequence, increases effect of competitive antagonists of GABA on root mean square noise (RMS) amplitude of holding current in electrophysiological recording. Figure: changes of RMS after application of SR 95531 and SR 95531 + Picrotoxin. BII makes significant an effect of SR 95531 applied alone.

PMID: 30205722

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