Chemical Name: (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
Biological ActivityBIX 02189 is a selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Identification of pharmacological inhibitors of the MEK5/ERK5 pathway.
Tatake et al.
Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells.
Lopez-Royuela et al.
Int.J.Biochem.Cell Biol., 2014;53:253
Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart.
Kimura et al.
Citation for BIX 02189
The citations listed below are publications that use Tocris products. Selected citations for BIX 02189 include:
1 Citation: Showing 1 - 1
Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders.
Authors: Liang Et al.
J Allergy Clin Immunol 2017;139:1217
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