BIX 02189

   
Product Datasheet
Catalog Number:4842
Chemical Name:(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
Product Details
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Biological Activity
Selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.
Technical Data
  • M.Wt:
    440.54
  • Formula:
    C27H28N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1265916-41-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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