Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine
Biological ActivityBL 1249 is a K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50 values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
Tertyshnikova et al.
Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures.
Gonczi et al.
Protein and chemical determinants of BL-1249 action and selectivity for K2P channels.
Pope et al.
ACS Chem.Neurosci., 2018;9:3153
Citation for BL 1249
The citations listed below are publications that use Tocris products. Selected citations for BL 1249 include:
1 Citation: Showing 1 - 1
Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
Authors: Fernandez-Fernandez Et al.
PLoS One 2018;13:e0199282
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Reviews for BL 1249
Average Rating: 5 (Based on 1 Review)
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Great potassium channel activator. Was studied on potassium channel expressed on human brain cells. The product performed well under experimental conditions and would purchase again.