Putative potassium channel activator; thought to act as a K2P
2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue in vitro
and in vivo
values are 1.26 and 21.0 μ
M for cultured bladder and aortic tissues respectively).
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BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
Tertyshnikova et al.
Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures.
Gonczi et al.