BL660-NO

Tocris Bioscience | Catalog # 7753

Nitric oxide activity-based sensing NIR bioluminescent probe
Tocris Bioscience

Key Product Details

Description

Nitric oxide activity-based sensing NIR bioluminescent probe
View all Bioluminescent Substrates »

Product Description

BL660-NO is an activity-based sensing (ABS) bioluminescent probe for near-infrared red (NIR) detection of nitric oxide (NO). BL660-NO is suitable for in vitro, live cell and deep tissue imaging. Used to visualize endogenous NO in vitro, and in murine models of liver and breast cancer. Used to investigate the effect of diet on tumor microenvironment (TME) in mice.

This product is a scalemic mixture of (S) and (R) enantiomers in which (S) is predominant. The exact ratio is batch specific and is expressed as an enantiomeric excess (e.e.) on the Certificate of Analysis.

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Product Specifications for BL660-NO

Molecular Weight

420.58

Formula

C24H28N4OS

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

N-(2-Aminophenyl)-2-((1E,3E)-4-(4-(diethylamino)phenyl)buta-1,3-dien-1-yl)-4,5-dihydrothiazole-4-carboxamide

InChI Key

LERSAEPSTKIDTF-PIHCAMFYSA-N

SMILES

O=C(NC1=C(N)C=CC=C1)C(CS2)N=C2/C=C/C=C/C(C=C3)=CC=C3N(CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.06 100

Preparing Stock Solutions for BL660-NO

The following data is based on the product molecular weight 420.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for BL660-NO

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BL660-NO

For research use only

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