Catalog Number: 5417
Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Biological Activity
p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.
Technical Data
  • M.Wt:
    360.41
  • Formula:
    C21H20N4O2
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    896705-16-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
    Peltonen et al.
    Cancer Cell, 2014;13:77
  2. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
    Colis et al.
    J.Med.Chem., 2014;57:4950
  3. Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
    Peltonen et al.
    PLoS ONE, 2010;5:e12996

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