BMH 21

Key Product Details

Product Description

BMH 21 is a p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Product Specifications for BMH 21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMH 21

The following data is based on the product molecular weight 360.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	55.49 mL	277.46 mL	554.92 mL
0.25 mM	11.10 mL	55.49 mL	110.98 mL
0.5 mM	5.55 mL	27.75 mL	55.49 mL
2.5 mM	1.11 mL	5.55 mL	11.10 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Colis Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 2014 PMID: 24847734
• Peltonen Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 2010 PMID: 20885994
• Peltonen A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 2014 PMID: 24434211

Product Documents for BMH 21