Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Biological ActivityBMH 21 is a p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Peltonen et al.
Cancer Cell, 2014;13:77
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
Colis et al.
Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
Peltonen et al.
PLoS ONE, 2010;5:e12996
Citation for BMH 21
The citations listed below are publications that use Tocris products. Selected citations for BMH 21 include:
1 Citation: Showing 1 - 1
Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction.
Authors: McCullough Et al.
Transl Psychiatry 2018;8:164
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