BMS 265246

Key Product Details

Product Description

BMS 265246 is a potent cyclin-dependent kinase 1 (cdk1) and cdk 2 inhibitor (IC₅₀ values are 5.6 - 71 and 6 - 14 nM, respectively). Also inhibits cdk4 and cdk5 in the sub micromolar range and cdk7 and cdk9 in the low micromolar range. Inhibits proliferation of HCT-116 colon cancer cells in vitro.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.

Product Specifications for BMS 265246

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 265246

The following data is based on the product molecular weight 345.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.79 mL	28.96 mL	57.91 mL
2.5 mM	1.16 mL	5.79 mL	11.58 mL
5 mM	0.58 mL	2.90 mL	5.79 mL
25 mM	0.12 mL	0.58 mL	1.16 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Misra 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 2003 PMID: 12824044

Product Documents for BMS 265246