BMS 299897

Catalog # Availability Size / Price Qty
2870/10
BMS 299897 | CAS No. 290315-45-6 | Secretase Inhibitors
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Description: Potent γ-secretase inhibitor

Chemical Name: 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Technical Data

M.Wt:
511.94
Formula:
C24H21ClF3NO4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
290315-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BMS 299897

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BMS as a inhibitor treatment is good for Hippocampal neuron
By Anonymous on 10/13/2019
Species: Human

Using more specific inhibitors, we ruled out the involvement of gamma -secretase (100 nM BMS 299897 and 250 nM DAPT) or matrix metalloproteinases 1, 2, 3, 7, 9, 14, and 17 (0.1–1 μM batimastat and marimastat), as their inhibitors failed to alter A beta O release

PMID: 28963439

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