BMS 299897

Tocris Bioscience | Catalog # 2870

Potent γ-secretase inhibitor
Tocris Bioscience

Key Product Details

Description

Potent γ-secretase inhibitor
View all Secretase Inhibitors »

Product Description

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Product Specifications for BMS 299897

Molecular Weight

511.94

Formula

C24H21ClF3NO4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid

CAS Number

290315-45-6

PubChem ID

11249248

InChI Key

IZAOBRWCUGOKNH-OAHLLOKOSA-N

SMILES

FC1=CC=[C@@]([C@H](N(C3=CC(F)=CC=C3F)S(C2=CC=C(Cl)C=C2)(=O)=O)C)C(CCCC(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.19 100
Ethanol 51.19 100

Preparing Stock Solutions for BMS 299897

The following data is based on the product molecular weight 511.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.20 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for BMS 299897

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS 299897

For research use only

Customer Reviews for BMS 299897 (2)

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  • works well
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    gamma -secretase (100 nM BMS 299897 and 250 nM DAPT)
    BMS 299897 2870
  • BMS as a inhibitor treatment is good for Hippocampal neuron
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 10/13/2019
    Using more specific inhibitors, we ruled out the involvement of gamma -secretase (100 nM BMS 299897 and 250 nM DAPT) or matrix metalloproteinases 1, 2, 3, 7, 9, 14, and 17 (0.1–1 μM batimastat and marimastat), as their inhibitors failed to alter A beta O release
    BMS 299897 2870

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