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BMS 299897

Catalog #: 2870
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2870/10
BMS 299897 | CAS No. 290315-45-6 | Secretase Inhibitors
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Description: Potent γ-secretase inhibitor

Chemical Name: 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Technical Data

M.Wt:
511.94
Formula:
C24H21ClF3NO4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
290315-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BMS 299897

The citations listed below are publications that use Tocris products. Selected citations for BMS 299897 include:

2 Citations: Showing 1 - 2

  1. APP upregulation contributes to retinal ganglion cell degeneration via JNK3.
    Authors: Liu Et al.
    Cell Death Differ  2018;25:661
  2. Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
    Authors: Pitt Et al.
    Mol Biol Cell  2017;28:2623

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